This medicine is a monoclonal antibody used to treat certain types of advanced lung cancer. It is also used to treat certain types of brain, kidney, colon, or rectal cancer. It is used with other cancer medicines. It may also be used to treat other conditions as determined by your doctor.
Follow the directions for using this medicine provided by your doctor. This medicine is usually administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. DO NOT USE THIS MEDICINE if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged in any way. DO NOT SHAKE the medicine. IF NAUSEA, VOMITING, OR LOSS OF APPETITE OCCURS, ask your doctor, nurse, or pharmacist for ways to lessen these effects. THIS MEDICINE IS USUALLY HANDLED AND STORED by a health care provider. If you are using this medicine at home, store this medicine as directed by your pharmacist or health care provider. KEEP THIS MEDICINE, as well as syringes and needles, out of reach of children and pets. IF YOU MISS A DOSE OF THIS MEDICINE, contact your doctor immediately to establish a new dosing schedule.
WARNING: SERIOUS STOMACH OR BOWEL PROBLEMS (eg, abscess, fistula, perforation) may occur with this medicine. These effects are not common, but may be serious and sometimes fatal. Tell your doctor right away if you develop unusual stomach pain along with constipation, fever, nausea, or vomiting. THE INCIDENCE OF WOUND HEALING PROBLEMS AND SURGICAL COMPLICATIONS, including serious and sometimes fatal complications, is greater in patients who use this medicine. Tell your doctor immediately if you notice any wounds that do not heal or if you have a surgical wound that opens up. Tell your doctor if you are scheduled to have surgery or if you have had surgery within the past 28 days. If possible, you should not use this medicine within 28 days before or after surgery and until the surgical wound is healed. Talk with your doctor for more information. THE RISK OF SEVERE AND SOMETIMES FATAL BLEEDING PROBLEMS is increased with this medicine. Patients who have severe bleeding or a recent history of coughing up blood should not use this medicine. Contact your doctor right away if you experience unusual bruising or bleeding, including severe or persistent nosebleed; coughing up blood; black, tarry stools; blood in the vomit or vomit that looks like coffee grounds; unusual or severe vaginal bleeding; or stroke symptoms (eg, confusion, slurred speech, vision problems, one-sided weakness). Some medicines or medical conditions may interact with this medicine. INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicines that you are taking. DO NOT TAKE THIS MEDICINE if you are also taking sunitinib. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking anticoagulants (eg, warfarin). DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor if you are scheduled for surgery or if you have a wound that has not fully healed. Inform your doctor of any other medical conditions, including a history of chest pain (eg, angina), high blood pressure, blood vessel problems (eg, stroke), bleeding problems, blood clots, coughing up blood, heart problems (eg, congestive heart failure, heart disease, heart attack), kidney problems, high amounts of protein in your urine, nervous system problems, stomach or bowel problems, allergies, pregnancy or if you are able to become pregnant, or breast-feeding. Tell your doctor if you have a low blood sodium level. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have severe bleeding, you have recently coughed up blood, or you have a tear or hole (perforation) in your stomach or bowels. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have a wound (including a surgical wound) that has not healed or that has split apart, or if you have had surgery within the last 28 days. Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
SIDE EFFECTS that may occur while using this medicine include back pain; changes in taste; constipation; diarrhea; dizziness; dry mouth; dry skin; headache; increased thirst; indigestion; loss of appetite; minor nosebleeds; mouth or tongue pain, swelling, or sores; muscle pain; nausea; pain, swelling, or redness at the injection site; stuffy or runny nose; tiredness; voice changes; vomiting; or weakness. If they continue or become bothersome, check with your doctor. THIS MEDICINE MAY CAUSE A SERIOUS BRAIN PROBLEM called reversible posterior leukoencephalopathy syndrome (RPLS). If RPLS occurs, symptoms may appear from 16 hours to 1 year after starting this medicine. Contact your doctor right away if you experience severe headache, seizures, sluggishness, confusion, loss of vision, or other vision changes. CONTACT YOUR DOCTOR IMMEDIATELY if you experience black, tarry stools; blood in the urine; burning, numbness, or tingling; chest pain; coughing up blood; decreased urination; fainting; fever, chills, or persistent sore throat; red, swollen, blistered, or peeling skin; seizures; severe or persistent headache or dizziness; severe or persistent nosebleed; severe or persistent stomach pain, constipation, nausea, or vomiting; severe or persistent weakness; shortness of breath; swelling of the hands, ankles, or feet; swelling or pain in the jaw; unusual bruising or bleeding; unusual or severe sweating; unusual weight gain or loss; vision loss, blurred vision, or other vision changes; vomit that looks like coffee grounds; wheezing; or wounds that do not heal. AN ALLERGIC REACTION to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash; hives; itching; difficulty breathing; tightness in the chest; or swelling of the mouth, face, lips, or tongue. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your healthcare provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms may include severe headache.
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when it is full. CHECK WITH YOUR PHARMACIST about how to dispose of unused medicine.